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Posted on: October 31 2023


Complex Regional Pain Syndrome (CRPS) is a debilitating condition that often arises after trauma or injury. When it manifests in the foot, it can severely impact mobility and quality of life. Traditional treatment approaches often involves a team approach, including physical therapy, pain medications, nerve blocks and psychosocial support, although it may not always yield the desired results. In recent years, a promising therapy involving 5% glucose perineural injections has emerged as a potential game-changer. This blog explores the intricacies of CRPS in the foot and sheds light on the innovative use of 5% glucose in its treatment.

Understanding Complex Regional Pain Syndrome in the Foot

CRPS in the foot is a challenging condition characterised commonly by excruciating chronic pain, swelling, changes in skin colour and temperature, abnormal sweating and hair growth and results in limited mobility. It often arises after an injury or surgery and can persist long after the initial trauma has healed. This chronic pain syndrome can significantly impede daily activities, making even simple tasks like walking or wearing shoes a painful ordeal.

The Role of 5% Glucose in Perineural Injection Therapy

5% glucose, or dextrose, has gained attention as a potential therapeutic agent for CRPS in the foot. The rationale behind this treatment lies in its hypothesized ability to modulate nerve function and reduce inflammation around affected nerves. By injecting a carefully prepared solution of 5% glucose subcutaneously near the affected nerves, ultimately alleviating pain and improving function.

The Treatment Process

Perineural injection therapy with 5% glucose is a specialised procedure. The treatment typically involves the following steps:

  1. Patient Assessment: A comprehensive evaluation of the patient’s medical history, symptoms, diagnostics and previous treatments is conducted to confirm the diagnosis and determine the suitability for perineural injection therapy.
  2. Precise Injection: Our podiatrists administers the 5% glucose solution using a fine diabetic needle under sterile conditions. The goal is to deliver the solution to the perineural tissue. Treatments are usually weekly, and the number of sessions required is anywhere from 3-6.
  3. Monitoring and Follow-up: Patients are closely monitored for changes in their symptoms, and changes in their pain score, and everyday activities.

The Promise of Relief

For many individuals suffering from CRPS in the foot, perineural injection therapy with 5% glucose offers a glimmer of hope. Early studies and anecdotal evidence suggest that this innovative approach holds significant potential in reducing pain and improving overall function. However, it’s important to note that individual responses to the treatment may vary, and further research is needed to establish its long-term efficacy.


Complex Regional Pain Syndrome in the foot is a challenging condition that can have a profound impact on a person’s quality of life. The emergence of 5% glucose perineural injection therapy as a treatment option provides renewed optimism for those struggling with this debilitating condition. While this innovative approach shows promise, it’s crucial to consult with a healthcare provider to determine the best course of action based on individual circumstances. Cheltenham Podiatry has been practicing this technique for almost a decade, and are experts in this technique.

Thor, J. A., Mohamed Hanapi, N. H., Halil, H., & Suhaimi, A. (2017). Perineural Injection Therapy in the Management of Complex Regional Pain Syndrome: A Sweet Solution to Pain. Pain Medicine, 18(10), 2041–2045.

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