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Prolotherapy is a safe and also an effective regenerative treatment. 

What is Prolotherapy?

Firstly, during a prolotherapy treatment, natural solution is injected into damaged tissue. As a result, this stimulates growth factors, and help  regenerate damaged  ligaments and tendons. Finally, it also improves nerve function, which assists in relieving pain.


Firstly, prolotherapy can be used to treat a range of podiatric conditions, which includes:

  • Osteoarthritis of knee, ankle, large toe and other foot joints
  • Bunion pain
  • Stubborn soft tissue injuries – heel pain, Achilles tendinopathy and plantar fasciitis, ligament damage and weakness (weak ankles), ankle pain, cuboid syndrome, runner’s knee, jumper’s knee and ITB syndrome
  • Neural/nerve pain - Morton’s neuroma, nerve trauma after surgery, nerve entrapments and constriction.

Additionally, it may be combined with other podiatric treatments, including other injection therapies, photobiomodulation, orthotics, footwear adjustments, paddings and exercise as necessary. In addition, nutritional supplements are often advised with Prolotherapy to encourage healing of the tissues. 

Finally, read more about Prolotherapy treatment here and view this video about Lateral Ankle Prolotherapy. 

Person Receiving Prolotherapy

At Cheltenham Podiatry, we use two forms of Prolotherapy:

Classical Hackett Prolotherapy:

A glucose with an anaesthetic solution is injected into the damaged tissue. 

In addition, when introduced into a joint, this releases growth factors that can help increase cartilage growth, reduces pain and inflammation.

Furthermore, it can be used in strengthening damaged ligaments (for example, weak ankles), aid in repairing damaged tendons and treating osteoarthritic joints. 

In conclusion, fortnightly to monthly injections are generally needed, usually for a course of 4-9 sessions. 

Lyftogt’s Perineural Prolotherapy:

Also known as Perineural Injection Therapy (PIT), this innovative advancement in regenerative medicine is able to reduce pain almost immediately. Furthermore, this is done by intervening in the inflammatory process and restoring normal nerve function. In addition, as nerves feed all our tissues, it can also be used to treat chronic musculoskeletal conditions, such as Achilles tendinopathy. Additionally, a medical grade dextrose solution is injected just under the skin with a small fine needle and no anaesthetic is required. 

In addition, between 3-8 sessions are usually needed , although in some cases 1-3 sessions may be sufficient. Additionally, an immediate reduction in pain after the first injection is experienced by most patients, with it lasting anywhere from hours to days.

In conclusion, pain is generally reduced by 20-40% with each subsequent treatment as the tissue progressively heals. 

Furthermore, Related research papers:

  • Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: Long term outcomes
    DavidRabago MarlonMundt AleksandraZgierska JessicaGrettie
  • Perineural Injection Therapy in the Management of Complex Regional Pain Syndrome: A Sweet Solution to Pain.
    JU ANN THOR, MD, NOR HANIM MOHAMED HANAPI, MBBS, HAZWANI HALIL, BSC, AND ANWAR SUHAIMI, MBBS, MREHABMED Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Book an appointment


Our friendly and professional podiatrists are fully trained and have years of experience. Therefore ensuring that you receive the best quality treatment and advice. 

Finally, to find out if prolotherapy treatment is right for you, book an appointment at Cheltenham Podiatry today. Or you can call our team on 03 9583 3093Alternatively, you can contact us using the contact form below.

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Picture Of Prolotherapy Treatment


It’s important to eat well before prolotherapy. If your appointment is early in the day, have a good-sized breakfast and include some protein, if possible. If your appointment is in the afternoon, have breakfast and lunch.

It is also advisable to stop taking anti-inflammatory medications a few days before prolotherapy because they can interfere with the procedure’s effectiveness.

The procedure will be performed by a physician specifically trained in prolotherapy so that you can be at ease throughout the entire process.

Generally, patients will have several treatments over intervals of four to six weeks. The amount of treatments you will need depends on a variety of factors, but in most cases, three to six treatments is enough.

Do not take any anti-inflammatory medications after prolotherapy, as this will decrease the treatment’s effectiveness. Light exercise will generally be fine after a few days, but it’s important to listen to your body. If you are in significant pain, don’t continue the exercise.